Artesunate 60mg Injection (Larinate)

Artesunate 60mg Injection (Larinate)

Larinate 60mg Injection contains Artesunate 60mg, a fast acting antimalarial medicine used primarily for the treatment of severe malaria. Artesunate belongs to the artemisinin class and rapidly reduces the number of malaria parasites in the bloodstream, making it an important treatment for patients who require injectable antimalarial therapy. WHO recommends intravenous or intramuscular artesunate for severe malaria.

Artesunate acts rapidly against malaria parasites during their blood stage. It is converted to the active compound dihydroartemisinin, which damages essential parasite proteins and cellular structures, helping reduce the parasite burden in the blood.

Larinate 60mg Injection is intended for administration by a qualified healthcare professional. The dose is calculated according to body weight and the severity of malaria. Injectable artesunate is generally followed by a complete course of an appropriate oral artemisinin based combination therapy once the patient can take oral medication.

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What is Artesunate 60mg Injection (Larinate) Used For?

Larinate 60mg Injection is primarily used for the emergency treatment of severe malaria.

Common Uses

• Severe malaria
• Severe Plasmodium falciparum malaria
• Malaria requiring rapid parenteral treatment
• Malaria in patients who cannot initially take oral medication
• Emergency treatment of severe malaria before transition to oral antimalarial therapy

WHO recommends injectable artesunate for adults and children with severe malaria.

How Artesunate 60mg Works

Artesunate rapidly targets malaria parasites in the bloodstream.

Mechanism of Action

• Converts rapidly to the active metabolite dihydroartemisinin.
• Damages essential proteins and cellular structures within malaria parasites.
• Rapidly reduces circulating parasite levels.
• Helps stop the progression of severe malaria.
• Supports clearance of malaria parasites from the bloodstream.

Its rapid antiparasitic activity makes injectable artesunate particularly valuable in severe malaria.

How to Use Artesunate 60mg Injection

Artesunate injection must be prepared and administered by a qualified healthcare professional.

Administration

• The dose is calculated according to body weight.
• WHO guidance recommends 2.4mg/kg IV or IM for adults and children weighing 20kg or more. Children under 20kg require a higher dose of 3mg/kg per dose under current WHO guidance.
• For severe malaria, treatment is given initially and repeated according to the recommended schedule, followed by daily administration until oral therapy can be taken.
• The injection must be properly reconstituted before administration.
• Once the patient can tolerate oral medication, treatment should be completed with a full course of an appropriate artemisinin based combination therapy.

Do not attempt to prepare or administer Artesunate 60mg Injection without appropriate medical training.

Benefits of Artesunate 60mg Injection

Key Benefits

• Rapid antimalarial activity.
• Recommended for severe malaria.
• Quickly reduces malaria parasite levels in the bloodstream.
• Available as an injectable formulation when oral treatment is not initially possible.
• Suitable for weight based dosing.
• Can be followed by oral artemisinin based combination therapy to complete treatment.

Possible Side Effects

Artesunate is generally well tolerated, but adverse reactions can occur.

Possible Side Effects

• Nausea
• Vomiting
• Headache
• Dizziness
• Abdominal discomfort
• Fever
• Injection site reactions
• Temporary changes in blood cell counts

Important Delayed Reaction

Delayed hemolysis can occur after treatment with injectable artesunate, particularly in patients treated for severe malaria. Medical follow up and blood count monitoring may therefore be appropriate after treatment.

Seek immediate medical attention for severe weakness, unusual bleeding, difficulty breathing, severe allergic reactions, dark urine, yellowing of the skin or eyes, or other concerning symptoms.

Safety and Precautions

Before treatment with Larinate 60mg Injection, consider the following precautions.

Important Considerations

• Artesunate injection should be administered by qualified healthcare professionals.
• Inform the healthcare team about any previous reactions to artesunate or other artemisinin medicines.
• Tell your healthcare provider about other medicines being taken.
• Patients treated for severe malaria may require monitoring of blood counts and clinical condition after treatment.
• Complete the recommended oral antimalarial treatment after parenteral therapy when the patient can tolerate oral medication.
• The product should be prepared and stored according to the manufacturer's instructions.

Supportive Care During Recovery

Recovery from malaria may require supportive care alongside antimalarial treatment.

Helpful Tips

• Maintain adequate hydration as advised by the healthcare team.
• Get sufficient rest.
• Follow the complete antimalarial treatment plan.
• Attend recommended follow up appointments.
• Complete the prescribed oral treatment after injectable therapy when instructed.
• Seek medical attention promptly if fever, weakness, confusion, breathing difficulties, or other symptoms worsen.

Final Thoughts

Larinate 60mg Injection (Artesunate) is a fast acting injectable antimalarial medicine primarily used for severe malaria. It rapidly reduces malaria parasites in the bloodstream and is recommended by WHO as a key treatment for severe malaria. After the patient improves sufficiently to take oral medication, a complete oral artemisinin based combination therapy should be given to complete treatment.

Medical Disclaimer

This information is provided for educational and informational purposes only and should not be considered medical advice, diagnosis, or treatment. Artesunate injection is a hospital or clinical treatment that requires appropriate medical supervision and administration.

Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Seek immediate medical attention for severe malaria symptoms or serious adverse reactions.

Products available on Rxmeds.store should only be used according to healthcare guidance and recommended instructions.